The article below peaks my interest since I still have no other reason for my blood clot/heart attack other than being told that I had "a lot of stress and bad luck". I wonder how the doctor officially wrote that sentence!? In fact, I am hoping to get something official in writing at my next appointment. It's a horrible feeling not knowing why. I always wanted to be a journalism major - the who, what, when, why and how is the first thing I learned (I didn't get very far in that journalism endeavor!). Anyhow, in this situation, the only answer I have pertains to who. The answer is, me.
I went through all sorts of genetic tests following my heart attack (lupus, leukemia, I can't remember them all...) yet everything came back negative. The reason I want to know isn't just a need to know based upon reaction, I want to know so I can try to prevent it from happening again. So, for now, I still mention every little thing I can think of as it comes to mind to my doctor, no matter how silly it may seem. I think I've been in the room to many times when my husband is watching the t.v. program 'House'! Probably more ridiculous is the fact that I still have a shoe box sized box with the empty bottles of the vitamin supplements/medications I was taking when I had my heart attack - as though some recall will occur and I will have the bottles with the manufacturing information that link the mysterious contents to my heart attack (again, too much 'House'). I need to begin to accept the fact that I will never know; that I have to look at people and say "stress and bad luck", and believe it myself. Well, on with the article (below):
Genetic Link to Heart Failure
ScienceDaily (Jan. 1, 2010) — A team of researchers, at Washington University School of Medicine, St Louis, has identified a group of 12 genetic variants in the HSPB7 gene that is associated with heart failure in humans.
The research is reported in the Journal of Clinical Investigation. The team, led by Gerald Dorn, used an approach they have recently developed that allows ultra-high-throughput targeted DNA sequencing to identify genetic variation in four genes with biological relevance to heart failure. They identified in a large group of Caucasian individuals with heart failure, 129 separate genetic variants in the four genes, including 23 that seemed to be novel.
Further analysis of 1117 Caucasian individuals with heart failure and 625 nonaffected Caucasians indicated that a block of 12 genetic variants in the HSPB7 gene was associated with heart failure. Confirmation of this association was provided by analysis of an independent group of individuals.
The authors hope to use the same approach to identify further genetic variants associated with heart failure, a disease that is influenced by multiple genetic factors.
Genetic Link to Heart Failure
ScienceDaily (Jan. 1, 2010) — A team of researchers, at Washington University School of Medicine, St Louis, has identified a group of 12 genetic variants in the HSPB7 gene that is associated with heart failure in humans.
The research is reported in the Journal of Clinical Investigation. The team, led by Gerald Dorn, used an approach they have recently developed that allows ultra-high-throughput targeted DNA sequencing to identify genetic variation in four genes with biological relevance to heart failure. They identified in a large group of Caucasian individuals with heart failure, 129 separate genetic variants in the four genes, including 23 that seemed to be novel.
Further analysis of 1117 Caucasian individuals with heart failure and 625 nonaffected Caucasians indicated that a block of 12 genetic variants in the HSPB7 gene was associated with heart failure. Confirmation of this association was provided by analysis of an independent group of individuals.
The authors hope to use the same approach to identify further genetic variants associated with heart failure, a disease that is influenced by multiple genetic factors.